Details

Autor(en) / Beteiligte

• Tulub, Alexander A.
• Stefanov, Vassily E.

Titel

Hidden symmetries of DNA molecule

Ist Teil von

• Journal of theoretical biology, 2017-03, Vol.416, p.144-148

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Despite the fact that DNA molecule is studied up and down, we know very little about the role of DNA triplets in coding amino acids and stop-codons. The paper aims to fill this gap through attracting spintronic ideas and carrying out QM/MM computations on a full-turn DNA fragment. The computations reveal two hidden symmetries: the spin splitting (the Rashba effect), confined within each triplet, and the quantum “phase” link between the triplet nature (in total, 64 triplets) and the corresponding amino acid and three stop-codons. The hidden symmetries become evident upon binding the magnesium cofactor to DNA triplets in 5’−3’ and 3’−5’ directions. •With no visual symmetries, DNA molecule possesses hidden symmetries.•Hidden symmetries are a result of binding DNA to magnesium cofactors.•Magnesium-bound nucleotide triplets reveal oppositely rotating electrons (Rashba effect).•Each nucleotide triplet has a specific spin polarization linked to 20 amino acids plus 3 stop-codons.•Each magnesium-bound triplet might be considered as a Berry-Chern-Tulub subgroup.