Details

Autor(en) / Beteiligte

• Fujino, Yusuke
• Attizzani, Guilherme F
• Tahara, Satoko
• Naganuma, Toru
• Takagi, Kensuke
• Yabushita, Hiroto
• Wang, Wei
• Tanaka, Kentaro
• Matsumoto, Takahiro
• Kawamoto, Hiroyoshi
• Yamada, Yuya
• Amano, Shinnosuke
• Watanabe, Yusuke
• Warisawa, Takayuki
• Sato, Tomohiko
• Mitomo, Satoru
• Kurita, Naoyuki
• Ishiguro, Hisaaki
• Hozawa, Koji
• Tsukahara, Takahiro
• Motosuke, Masahiro
• Bezerra, Hiram G
• Nakamura, Shotaro
• Nakamura, Sunao

Titel

Difference in vascular response between sirolimus-eluting- and everolimus-eluting stents in ostial left circumflex artery after unprotected left main as observed by optical coherence tomography

Ist Teil von

• International journal of cardiology, 2017-03, Vol.230, p.284-292

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT). Methods We prospectively enrolled 38 consecutive patients with ULM disease, who were treated with single-stent procedure using DES, crossover the ULM-left anterior descending artery (LAD) followed by KBT. Twelve patients were treated with sirolimus-eluting stents (SES) and 26 patients were treated with everolimus-eluting stents (EES). OCT was conducted at post-PCI and 9-month follow-up. We evaluated the DES–vessel interactions and number of stent struts at the side branch (LCX) ostium (SO) at post-PCI, and compared the narrowing of ostial area at LCX between SES and EES. Results Post-procedure, the number of stent struts at SO was significantly higher in SES compared to EES (median 14.47% vs 0.19%, p < 0.001). The narrowing of LCX ostial area at follow-up was more pronounced in SES compared with EES (29.16% vs 2.46%, respectively, p < 0.001). Linear regression analysis showed a high correlation between the number of stent struts in LCX ostium and ostial area narrowing ( r = 0.771, p < 0.001). Conclusions OCT showed differences between EES– and SES–vessel interactions at ULM bifurcation PCI. Number of LCX ostium struts at post-PCI impacted the narrowing of ostial area at 9-month follow-up.