Details

Autor(en) / Beteiligte

• Griseri, Guido
• Ceriotti, Michela
• Percivale, Andrea
• Franceschi, Angelo
• Santori, Gregorio
• Benasso, Marco
• Pellicci, Riccardo

Titel

Two-stage Hepatectomy in Two Regional District Community Hospitals: Perioperative Safety and Long-Term Survival

Ist Teil von

• Tumori, 2017-03, Vol.103 (2), p.170-176

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Introduction Surgical resection offers the best chance of cure for patients with colorectal liver metastases (CRLMs). Two-stage hepatectomy (TSH) has been demonstrated to be safe and effective to obtain curative resection in patients with multiple, bilobar CRLMs that are unresectable in a single procedure. Up to now TSH has been the prerogative of dedicated liver surgery centers. The aim of this study was to assess the safety and effectiveness of TSH also in community hospitals. Methods Of 294 patients operated on for CRLMs between September 1997 and June 2012 in 2 district community hospitals (belonging to the same regional healthcare district), 43 (14.6%) were scheduled for TSH. Thirty-eight/43 received neoadjuvant and/or bridge chemotherapy (2 neoadjuvant only, 4 neoadjuvant and bridge, 32 bridge only). Results The mean follow-up was 35.74 ± 29.53 months. Five-year overall survival (OS) was 31.4%, with a median survival time of 31 months. Twenty-nine patients completed the planned procedure (OS: 42.9%; median 47 months), while 14 did not because of disease progression (OS: 0%; median 13 months). No operative mortality occurred within the first 90 days either after the first or second stage. Conclusions Our results suggest good efficacy and safety of TSH even when performed in a community hospital setting. Shifting patient selection from neoadjuvant to bridge chemotherapy had no impact on outcome once the clearing of the liver had been achieved. In patients presenting with synchronous CRLMs, simultaneous colorectal resection and clearing of the less involved hemiliver as the first surgical step is feasible without any negative impact on outcome.