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Evaluation of proposed staging systems for human papillomavirus‐related oropharyngeal squamous cell carcinoma
Cancer, 2017-05, Vol.123 (10), p.1768-1777
Malm, Ian‐James
Fan, Caleb J.
Yin, Linda X.
Li, David X.
Koch, Wayne M.
Gourin, Christine G.
Pitman, Karen T.
Richmon, Jeremy D.
Westra, William H.
Kang, Hyunseok
Quon, Harry
Eisele, David W.
Fakhry, Carole
2017
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Malm, Ian‐James
Fan, Caleb J.
Yin, Linda X.
Li, David X.
Koch, Wayne M.
Gourin, Christine G.
Pitman, Karen T.
Richmon, Jeremy D.
Westra, William H.
Kang, Hyunseok
Quon, Harry
Eisele, David W.
Fakhry, Carole
Titel
Evaluation of proposed staging systems for human papillomavirus‐related oropharyngeal squamous cell carcinoma
Ist Teil von
Cancer, 2017-05, Vol.123 (10), p.1768-1777
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND Patients with human papillomavirus (HPV)‐related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV‐negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC‐7ed) staging system does not account for the prognostic advantage observed with HPV‐positive OPC. The purpose of the current study was to validate and compare 2 recently proposed staging systems for HPV‐positive OPC. METHODS Patients treated for HPV‐positive OPC from 2005 to 2015 at Johns Hopkins Hospital (JHH) were included for analysis. The International Collaboration on Oropharyngeal cancer Network for Staging (ICON‐S) and The University of Texas MD Anderson Cancer Center (MDACC) staging systems were applied and survival was calculated using Kaplan‐Meier methods. Cox proportional hazard regression was used to determine the relationship between stage of disease and survival. Models were compared using the Akaike information criterion (AIC). RESULTS A total of 435 patients were eligible for analysis. There was a dramatic shift in lymph node category and overall stage of disease when ICON‐S and MDACC stage were applied to the JHH cohort. There was superior stratification of overall survival and progression‐free survival by ICON‐S stage. Both proposed models had an improved fit based on AIC scores (P<.001 for both) over the AJCC‐7ed. The ICON‐S staging system had the lowest AIC score, and thus a better fit within the JHH population. CONCLUSIONS The current analysis provides external validation for both staging systems in an independent and heterogeneously treated patient population. Although the MDACC staging system is an improvement over the AJCC‐7ed, the ICON‐S stage provides superior stratification of overall and progression‐free survival, thereby supporting its use as the updated AJCC staging system for OPC. Cancer 2017;123:1768–1777. © 2017 American Cancer Society. In a cohort of patients who were treated heterogeneously (including primary surgery), the International Collaboration on Oropharyngeal cancer Network for Staging (ICON‐S) staging system appears to provide superior stratification of overall and progression‐free survival. While providing external validation for both staging systems, the current analysis supports the use of the ICON‐S staging system in the anticipated update to the American Joint Committee on Cancer staging system for oropharyngeal cancer.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.30512
Titel-ID: cdi_proquest_miscellaneous_1855789006
Format
–
Schlagworte
Aged
,
Cancer
,
Carcinoma, Squamous Cell - complications
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - therapy
,
Carcinoma, Squamous Cell - virology
,
Collaboration
,
Disease-Free Survival
,
Female
,
Head and Neck Neoplasms - complications
,
Head and Neck Neoplasms - pathology
,
Head and Neck Neoplasms - therapy
,
Head and Neck Neoplasms - virology
,
Human papillomavirus
,
Humans
,
International cooperation
,
Kaplan-Meier Estimate
,
Lymph
,
Lymph nodes
,
Lymph Nodes - pathology
,
Male
,
Middle Aged
,
Neck
,
Neoplasm Staging
,
Oncology
,
Oropharyngeal cancer
,
Oropharyngeal Neoplasms - complications
,
Oropharyngeal Neoplasms - pathology
,
Oropharyngeal Neoplasms - therapy
,
Oropharyngeal Neoplasms - virology
,
Papillomaviridae
,
Papillomavirus Infections - complications
,
Papillomavirus Infections - pathology
,
Patients
,
Prognosis
,
Proportional Hazards Models
,
Regression analysis
,
Reproducibility of Results
,
Retrospective Studies
,
Squamous cell carcinoma
,
Squamous Cell Carcinoma of Head and Neck
,
Surgery
,
Survival
,
survival analysis
,
Survival Rate
,
Throat cancer
,
TNM stage
,
Upgrading
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