Details

Autor(en) / Beteiligte

• Singh, Surabhi
• Gupta, Bhuvanesh

Titel

Size-controlled preparation of nanosoy for potential biomedical applications

Ist Teil von

• Polymer international, 2016-12, Vol.65 (12), p.1373-1381

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2016

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Soy protein isolate nanoparticles (nanosoy) have significant applications in drug delivery, wound care systems and tissue engineering. We report an optimum technique named nanoprecipitation which enabled one‐step formation of near‐monodisperse nanosoy based on solvent displacement. Excellent control over protein aggregation was achieved, producing nanoparticles in the size range of 5–15 nm. The effect of various process parameters such as temperature, solvent/non‐solvent ratio, crosslinker content and type of surfactant on the particle size was investigated. The structural and morphological features were analysed using dynamic light scattering, X‐ray diffraction and high‐resolution transmission electron microscopy. The morphological examination indicated that the particles formed were spherical in shape and further reduction in the average particle diameter was achieved by reducing the temperature and solvent/non‐solvent ratio of the reaction medium. Surface charge and stability of nanosoy dispersions were analysed using zeta potential measurements. Further, ciprofloxacin release was monitored using nanosoy as a drug carrier. This technique provides an effective and straightforward approach offering considerable advantages in terms of economic, technical and environmental performance. © 2016 Society of Chemical Industry Nanoparticles of soy protein isolate (SPI) were synthesized by maintaining an optimum balance between simplicity of the preparation technique and control over size to achieve maximum monodispersity and stability.