Journal of Oral Science, 2017, Vol.59(1), pp.87-91
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts
- Ist Teil von
- Journal of Oral Science, 2017, Vol.59(1), pp.87-91
- Ort / Verlag
- Japan: Nihon University School of Dentistry
- Erscheinungsjahr
- 2017
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1343-4934eISSN: 1880-4926DOI: 10.2334/josnusd.16-0388Titel-ID: cdi_proquest_miscellaneous_1855335061
- Format
- –
- Schlagworte
- Acrylic Resins - pharmacology, cell culture, Cells, Cultured, Composite Resins - pharmacology, Cytokine Receptor gp130 - genetics, cytokines, cytotoxicity, Dentistry, Fibroblasts - metabolism, Gene Expression Regulation - drug effects, Gingiva - cytology, Gingiva - metabolism, Humans, inflammation, interleukin-6, Interleukin-6 - genetics, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-6 - genetics, Reverse Transcriptase Polymerase Chain Reaction, Transcription, Genetic - drug effects