Brain, behavior, and immunity, 2017-01, Vol.59, p.219-232
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice
- Ist Teil von
- Brain, behavior, and immunity, 2017-01, Vol.59, p.219-232
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Hemokinin-1 exerts anxiolytic and anti-depressant-like actions in mouse models. • Stress-induced neuronal activation is decreased in hemokinin-1-deficient mice. • Deleting and blocking the NK-1 receptors decrease depression-like behaviour. • Hemokinin-1 regulates stress/depression via unknown target-mediated mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2016.09.004Titel-ID: cdi_proquest_miscellaneous_1855081000
- Format
- –
- Schlagworte
- Allergy and Immunology, Anhedonia, Animals, Anti-Anxiety Agents - pharmacology, Anxiety - genetics, Anxiety - psychology, Behavior, Depression - genetics, Depression - psychology, Elevated plus maze test, Food Preferences, Forced swim test, Fos immunohistochemistry, Genes, fos, Hindlimb Suspension, Light-dark box test, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Open field test, Protein Precursors - genetics, Protein Precursors - physiology, Psychiatry, Receptors, Neurokinin-1 - genetics, Substance P - genetics, Sucrose preference test, Tachykinins, Tachykinins - genetics, Tachykinins - physiology, Tail suspension test