Brain, behavior, and immunity, 2017-01, Vol.59, p.118-134
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Sympathetic Nervous System Promotes Hepatocarcinogenesis by Modulating Inflammation through Activation of Alpha1-adrenergic Receptors of Kupffer Cells
- Ist Teil von
- Brain, behavior, and immunity, 2017-01, Vol.59, p.118-134
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • The sympathetic nervous system (SNS) infiltrates the liver and promotes hepatocarcinogenesis. • A high density of sympathetic nerve fibers is associated with poor prognosis of hepatocellular carcinoma (HCC) patients. • The SNS promotes the activation of Kupffer cells (KCs) via α1-adrenergic receptors in hepatocarcinogenesis. • The SNS promotes hepatocarcinogenesis by modulating the activity of KCs and liver inflammation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2016.08.016Titel-ID: cdi_proquest_miscellaneous_1855074028
- Format
- –
- Schlagworte
- Adult, Aged, Allergy and Immunology, Alpha1-adrenergic receptor, Animals, Carcinogenesis - pathology, Carcinoma, Hepatocellular - pathology, Female, Hepatocellular carcinoma, Humans, Inflammation - pathology, Interleukin-6 - metabolism, Kupffer cell, Kupffer Cells, Liver Neoplasms - chemically induced, Liver Neoplasms - pathology, Liver Neoplasms, Experimental - chemically induced, Liver Neoplasms, Experimental - pathology, Male, Middle Aged, Nerve Fibers - pathology, Prognosis, Psychiatry, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-1, Retrospective Studies, Sympathetic nervous system, Sympathetic Nervous System - pathology, Transforming Growth Factor beta - biosynthesis