Details

Autor(en) / Beteiligte

• Huan, Hong-bo
• Wen, Xu-dong
• Chen, Xue-jiao
• Wu, Lin
• Wu, Li-li
• Zhang, Liang
• Yang, Da-peng
• Zhang, Xia
• Bie, Ping
• Qian, Cheng
• Xia, Feng

Titel

Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells

Ist Teil von

• Brain, behavior, and immunity, 2017-01, Vol.59, p.118-134

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • The sympathetic nervous system (SNS) infiltrates the liver and promotes hepatocarcinogenesis. • A high density of sympathetic nerve fibers is associated with poor prognosis of hepatocellular carcinoma (HCC) patients. • The SNS promotes the activation of Kupffer cells (KCs) via α1-adrenergic receptors in hepatocarcinogenesis. • The SNS promotes hepatocarcinogenesis by modulating the activity of KCs and liver inflammation.