International journal of antimicrobial agents, 2017-02, Vol.49 (2), p.204-211
2017
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- Autor(en) / Beteiligte
- Titel
- Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis
- Ist Teil von
- International journal of antimicrobial agents, 2017-02, Vol.49 (2), p.204-211
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2017
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights • Gentamicin pharmacokinetics are highly variable in critically ill patients. • Albumin and creatinine clearance are major covariates for gentamicin concentration. • Higher starting gentamicin doses may be needed for patients with hypoalbuminaemia. • Serum creatinine and the Cockcroft–Gault formula overestimate gentamicin clearance. • Urinary creatinine clearance correlates best with gentamicin clearance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0924-8579eISSN: 1872-7913DOI: 10.1016/j.ijantimicag.2016.10.022Titel-ID: cdi_proquest_miscellaneous_1854616274
- Format
- –
- Schlagworte
- Adult, Aged, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - pharmacokinetics, Creatinine - blood, Creatinine - metabolism, Critical Illness, Female, Gentamicin, Gentamicins - administration & dosage, Gentamicins - pharmacokinetics, Humans, Hypoalbuminaemia, Infectious Disease, Intensive Care Units, Kidney Function Tests, Male, Metabolic Clearance Rate, Middle Aged, Population pharmacokinetics, Renal function, Retrospective Studies, Serum - chemistry, Serum Albumin - analysis, Young Adult