Details

Autor(en) / Beteiligte

• Agrawal, Gaurav
• Borody, Thomas
• Turner, Robert
• Leis, Sharyn
• Campbell, Jordana

Titel

Combining infliximab, anti-MAP and hyperbaric oxygen therapy for resistant fistulizing Crohn's disease

Ist Teil von

• Future science OA, 2015, Vol.1 (4), p.FSO77-FSO77

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• BACKGROUNDFistulizing Crohn's disease (CD) presents a therapeutic challenge as fistulae are notoriously difficult to heal. Mycobacterium avium ss paratuberculosis (MAP) treatment in CD is gaining attention. AIMWe evaluated healing of CD fistula(e) using a novel combination therapy. STUDYNine consecutive patients who failed to heal fistulae on conventional treatment including anti-TNF, were treated with at least three doses of infliximab, 18-30 courses of hyperbaric oxygen therapy and anti-MAP antibiotics comprising rifabutin, clarithromycin and clofazimine. RESULTSAll patients achieved complete healing of fistulae by 6-28 weeks and follow-up for mean 18 months. CONCLUSIONCombining infliximab, hyperbaric oxygen therapy and anti-MAP, seems to enable healing of recalcitrant fistulae and although a small case series, all nine patients achieved complete healing.