Details

Autor(en) / Beteiligte

• You, Shoujiang, MD
• Zhong, Chongke, MD
• Zheng, Danni, BPharm
• Xu, Jiaping, MB
• Zhang, Xia, MD
• Liu, Huihui, MD
• Zhang, Yanlin, MD, PhD
• Shi, Jijun, MD
• Huang, Zhichao, MD
• Cao, Yongjun, MD, PhD
• Liu, Chun-Feng, MD, PhD

Titel

Monocyte to HDL cholesterol ratio is associated with discharge and 3-month outcome in patients with acute intracerebral hemorrhage

Ist Teil von

• Journal of the neurological sciences, 2017-01, Vol.372, p.157-161

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Monocyte and monocyte to high-density lipoprotein ratio (MHR) recently emerged as markers of inflammation and have been reported to be novel prognostic indicators of cardiovascular diseases. We investigated the association of monocyte and MHR with hospital discharge and 3-month outcome after acute intracerebral hemorrhage (ICH). Methods A total of 316 patients with acute ICH were enrolled from November 2011 to March 2014. Demographic characteristics, lifestyle risk factors, medical history, admission laboratory parameters, and monocyte level were recorded. Clinical outcome was disability or death (defined as having a modified Rankin Scale score ≥ 2) upon discharge or at 3 months. Results 202 patients (63.9%) experienced disability or death at hospital discharge, and 176 patients (55.7%) at 3 months post-ICH. Admission monocyte level was associated with clinical outcome at 3 months (adjusted OR, 4.17; 95% CI, 1.45 – 12.00; P -trend = 0.028) when highest and lowest quartiles were compared. However, no significant association was found between monocyte and discharge outcome ( P -trend = 0.102). Compared to the lowest category of MHR, the highest category was associated with a 3.87-fold increase in the odds of disability or death at discharge (95% CI, 1.17 – 12.76; P -trend = 0.045) and 3.08-fold increased odds of disability or death at 3-month (95% CI, 1.05 – 9.08; P -trend = 0.024). Conclusions In patients with acute ICH, higher MHR was associated with increased risk of disability or death at discharge and at 3 months post-ICH, however higher monocyte was only associated with increased risk of 3-month disability or death.