Nature reviews. Genetics, 2002-10, Vol.3 (10), p.790-801
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Mouse models of male infertility
- Ist Teil von
- Nature reviews. Genetics, 2002-10, Vol.3 (10), p.790-801
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-0056eISSN: 1471-0064DOI: 10.1038/nrg911Titel-ID: cdi_proquest_miscellaneous_18528402
- Format
- –
- Schlagworte
- Animal models in research, Animals, Causes of, Cell Differentiation - physiology, Cells, Disease Models, Animal, Fertility, Follicle Stimulating Hormone - physiology, Genetic aspects, Genetic research, Genetics, Genomes, Germ Cells - physiology, Gonadotropin-Releasing Hormone - physiology, Humans, In vitro fertilization, Infertility, Infertility, Male, Infertility, Male - pathology, Infertility, Male - physiopathology, Luteinizing Hormone - physiology, Male, Meiosis - physiology, Men, Mice, Motility, Multiple births, Mutagenesis, Sperm, Spermatogenesis, Spermatogenesis - physiology, Testis - anatomy & histology, Testis - physiology