Details

Autor(en) / Beteiligte

• Granica, Sebastian
• Fusani, Pietro
• Stanisławska, Iwona
• Piwowarski, Jakub P.
• Melck, Dominique
• Motta, Andrea
• Zidorn, Christian

Titel

Monoterpenoids from the traditional North Italian vegetable Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae)

Ist Teil von

• Food chemistry, 2017-04, Vol.221, p.1851-1859

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •Metabolites of young shoots of Aruncus dioicus var. vulgaris were investigated.•Eight monoterpenoids were isolated and their structures were elucidated.•Five of the eight compounds represent previously undescribed natural products.•The distribution in different plant organs was studied by HPLC-DAD-MS.•Six of the eight monoterpenoids were also detected in A. dioicus var. aethusifolius. Investigations of young shoots of Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae), collected from the wild and used as vegetables in alpine provinces of Italy, yielded eight monoterpenoids. Besides known compounds, aruncin A, aruncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and aruncides D and E, were identified. Based on results from the full synthesis of aruncin B, structures of aruncin A and aruncide A were revised. Structures were established by HR mass spectrometry and extensive 1D and 2D NMR spectroscopy and based on data from synthetic aruncin B. An HPLC-DAD-ESI-MS method was developed to investigate the distribution of the monoterpenoids in different organs of Aruncus dioicus var. vulgaris and in aerial parts of A. dioicus var. aethusifolius (H.Lév.) H.Hara [Syn.: Aruncus aethusifolius (H.Lév.) Nakai]. Preliminary bioactivity studies moreover indicated weak cytotoxicity for some of the compounds against human prostrate adenocarcinoma cells.