Details

Autor(en) / Beteiligte

• Nel, Annalene
• van Niekerk, Neliëtte
• Kapiga, Saidi
• Bekker, Linda-Gail
• Gama, Cynthia
• Gill, Katherine
• Kamali, Anatoli
• Kotze, Philip
• Louw, Cheryl
• Mabude, Zonke
• Miti, Nokuthula
• Kusemererwa, Sylvia
• Tempelman, Hugo
• Carstens, Hannelie
• Devlin, Brid
• Isaacs, Michelle
• Malherbe, Mariëtte
• Mans, Winel
• Nuttall, Jeremy
• Russell, Marisa
• Ntshele, Smangaliso
• Smit, Marlie
• Solai, Leonard
• Spence, Patrick
• Steytler, John
• Windle, Kathleen
• Borremans, Maarten
• Resseler, Sophie
• Van Roey, Jens
• Parys, Wim
• Vangeneugden, Tony
• Van Baelen, Ben
• Rosenberg, Zeda

Titel

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

Ist Teil von

• The New England journal of medicine, 2016-12, Vol.375 (22), p.2133-2143

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Preventing HIV-1 infection, especially with female-controlled approaches, is a high priority. In this trial in South Africa and Uganda, a dapivirine vaginal ring was associated with a rate of acquisition of HIV-1 infection that was approximately 30% lower than that with placebo. In 2014, approximately 36.9 million people worldwide were living with human immunodeficiency virus (HIV) infection. 1 Rates of new HIV infection among adolescent girls and young women remain high in Eastern and Southern Africa, 2 which underscores the need for the development of safe and effective tools against HIV infection that women initiate themselves. 3 – 5 Self-inserted vaginal rings, which provide a sustained release of antiretroviral drugs over time, have the potential to offer women a prevention option that does not require daily or pericoital use. 6 The International Partnership for Microbicides (IPM) developed a monthly self-administered vaginal ring that contains the nonnucleoside reverse-transcriptase . . .