International journal of antimicrobial agents, 2017-01, Vol.49 (1), p.88-92
2017
Details
- Autor(en) / Beteiligte
- Titel
- Repurposing the anticancer drug mitomycin C for the treatment of persistent acinetobacter baumannii infections
- Ist Teil von
- International journal of antimicrobial agents, 2017-01, Vol.49 (1), p.88-92
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Acinetobacter baumannii is one of the main emergent pathogens owing to the high frequency of infections and its multidrug resistance. • The anticancer drug mitomycin C (MMC) is able to kill A. baumannii exponential-phase, stationary-phase and biofilm cells. • MMC is able to rescue Galleria mellonella larvae against otherwise lethal doses of reference and clinical A. baumannii strains, even those with multidrug resistance sensitive only to the highly nephrotoxic antibiotic colistin.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0924-8579eISSN: 1872-7913DOI: 10.1016/j.ijantimicag.2016.08.022Titel-ID: cdi_proquest_miscellaneous_1852664536
- Format
- –
- Schlagworte
- Acinetobacter baumannii - drug effects, Acinetobacter baumannii - growth & development, Acinetobacter Infections - drug therapy, Acinetobacter Infections - microbiology, Animals, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - pharmacology, Antibiotic resistance, Antibiotics, Antineoplastic - administration & dosage, Antibiotics, Antineoplastic - pharmacology, Anticancer drugs, Cisplatin - pharmacology, Disease Models, Animal, Drug Repositioning, Drug repurposing, Fluorouracil - pharmacology, Infectious Disease, Larva - microbiology, Lepidoptera - microbiology, Melphalan - pharmacology, Microbial Sensitivity Tests, Microbial Viability - drug effects, Mitomycin - administration & dosage, Mitomycin - pharmacology, Survival Analysis, Treatment Outcome