Details

Autor(en) / Beteiligte

• Saitovitch, Ana, PhD
• Rechtman, Elza
• Lemaitre, Hervé, PhD
• Douard, Elise
• Chabane, Nadia, MD
• Philippe, Anne, MD
• Grevent, David, MD
• Calmon, Raphael, MD
• Brunelle, Francis, MD
• Boddaert, Nathalie, MD
• Zilbovicius, Monica, MD

Titel

2.20 RESTING-STATE CEREBRAL BLOOD FLOW IN THE SUPERIOR TEMPORAL SULCUS CORRELATES WITH SOCIAL PERCEPTION IMPAIRMENTS IN CHILDREN WITH AUTISM SPECTRUM DISORDER

Ist Teil von

• Journal of the American Academy of Child and Adolescent Psychiatry, 2016-10, Vol.55 (10), p.S127-S127

Ort / Verlag

Baltimore: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• Objectives: In this study, we aimed to objectify social perception process in children with ASD using eye tracking to investigate a putative correlation between social perception impairments and rest functional brain activity. For this purpose, MRI arterial spin labeling (ASL) was used to measure rest cerebral blood flow (rCBF). Methods: Sixteen young children with ASD (age 5.0 ± 2.3 years; age range 2.3-10 years), diagnosed by DSM-IV-Revised and Autism Diagnostic Interview Revised (ADI-R), participated in this study and underwent an eye-tracking study followed by an MRI-ASL study. Tobii T120 eye tracker was used to measure the participant's number of fixations to the eyes of the characters during passive visualization of social scenes. MRI-ASL was used to measure rCBF. Whole-brain regression analyses were performed on the smoothed and normalized ASL images using the number of fixations to the eyes as covariate within SPM8 (www.fil.ion.ucl.ac.uk/spm). Results: ASL-MRI whole-brain analyses showed a significant positive correlation between the number of fixations to the eyes and rCBF in the right posterior superior temporal sulcus (pSTS) (P < 0.001 uncorrected). Children who looked less to the eyes of characters during visualization of social scenes had the lower rCBF values in the right pSTS. Conclusions: These results showed for the first time a correlation between a social behavior and a functional brain activity at rest, even though the measurements were unrelated and performed separately. This correlation suggests that social behavior in children with ASD is associated with, and might be predicted by, the level of functional activity at rest within the STS.