Details

Autor(en) / Beteiligte

• Welge, Jeffrey A., PhD
• Saliba, Lawrence J., BS
• Strawn, Jeffrey R., MD
• Eliassen, James C., PhD
• Patino, L. Rodrigo, MD
• Adler, Caleb M., MD
• Weber, Wade, MS
• Schneider, Marguerite Reid, BA
• Barzman, Drew H., MD
• Strakowski, Stephen M., MD
• DelBello, Melissa P., MD
• McNamara, Robert K., PhD

Titel

Neurofunctional Differences Among Youth With and At Varying Risk for Developing Mania

Ist Teil von

• Journal of the American Academy of Child and Adolescent Psychiatry, 2016-11, Vol.55 (11), p.980-989

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• Abstract Objective To examine prefrontal and amygdala activation during emotional processing in youth with or at varying risk for developing mania to identify candidate central prodromal risk biomarkers. Method Four groups of medication-free adolescents (10-20 years) participated: adolescents with first-episode bipolar I disorder (BP-I, n =32), adolescents with a parent with bipolar disorder and a depressive disorder (at-risk depressed, ARD, n =32), healthy adolescents with a parent with bipolar disorder (at-risk healthy, ARH, n =32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison, HC, n =32). Participants underwent functional magnetic resonance imaging (fMRI) while performing a continuous performance task with emotional and neutral distracters (CPT-END). Region of interest (ROI) analyses were performed for the bilateral amygdala, as well as subregions of the ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC). Results Overall, we did not observe group differences in bilateral amygdala and VLPFC (Brodmann area [BA] 45/47) activation during emotional or neutral stimuli. The BP-I group exhibited lower right pregenual ACC activation compared with HC, and activation in the left BA 44 was greater in the ARH and ARD groups compared with HC. BPD and ARD groups exhibited blunted activation in the right BA10 compared with the ARH group. Conclusion During emotional processing amygdala and VLPFC (BA 45/47) activation does not differ in youth with or at increasing risk for bipolar I disorder. However, blunted pregenual ACC activation in first-episode mania may represent an illness biomarker, and greater prefrontal BA10 and BA 44 activations in at-risk youth may represent a biomarker of risk or resilience warranting additional investigation in prospective longitudinal studies.