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Homeobox A9 directly targeted by miR-196b regulates aggressiveness through nuclear Factor-kappa B activity in non-small cell lung cancer cells
Molecular carcinogenesis, 2016-12, Vol.55 (12), p.1915-1926
Yu, Seong-Lan
Lee, Dong Chul
Sohn, Hyun Ahm
Lee, Soo Young
Jeon, Hyo Sung
Lee, Joon H.
Park, Chang Gyo
Lee, Hoi Young
Yeom, Young Il
Son, Ji Woong
Yoon, Yoo Sang
Kang, Jaeku
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yu, Seong-Lan
Lee, Dong Chul
Sohn, Hyun Ahm
Lee, Soo Young
Jeon, Hyo Sung
Lee, Joon H.
Park, Chang Gyo
Lee, Hoi Young
Yeom, Young Il
Son, Ji Woong
Yoon, Yoo Sang
Kang, Jaeku
Titel
Homeobox A9 directly targeted by miR-196b regulates aggressiveness through nuclear Factor-kappa B activity in non-small cell lung cancer cells
Ist Teil von
Molecular carcinogenesis, 2016-12, Vol.55 (12), p.1915-1926
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
MicroRNAs (miRNAs) are recognized as crucial posttranscriptional regulators of gene expression, and play critical roles as oncogenes or tumor suppressors in various cancers. Here, we show that miR‐196b is upregulated in mesenchymal‐like‐state non‐small cell lung cancer (NSCLC) cells and lung cancer tissues. Moreover, miR‐196b upregulation stimulates cell invasion and a change in cell morphology to a spindle shape via loss of cell‐to‐cell contacts. We identified homeobox A9 (HOXA9) as a target gene of miR‐196b by using public databases such as TargetScan, miRDB, and microRNA.org. HOXA9 expression is inversely correlated with miR‐196b levels in clinical NSCLC samples as compared to that in corresponding control samples, and with the migration and invasion of NSCLC cells. Ectopic expression of HOXA9 resulted in a suppression of miR‐196b‐induced cell invasion, and HOXA9 reexpression increased E‐cadherin expression. Furthermore, HOXA9 potently attenuated the expression of snail family zinc finger 2 (SNAI2/SLUG) and matrix metallopeptidase 9 (MMP9) by controlling the binding of nuclear factor–kappa B to the promoter of SLUG and MMP9 genes, respectively. Therefore, we suggest that HOXA9 plays a central role in controlling the aggressive behavior of lung cancer cells and that miR‐196b can serve as a potential target for developing anticancer agents. © 2015 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0899-1987
eISSN: 1098-2744
DOI: 10.1002/mc.22439
Titel-ID: cdi_proquest_miscellaneous_1850771320
Format
–
Schlagworte
Carcinoma, Non-Small-Cell Lung - genetics
,
Carcinoma, Non-Small-Cell Lung - metabolism
,
Carcinoma, Non-Small-Cell Lung - pathology
,
Cell Line, Tumor
,
Cellular biology
,
EMT
,
Epithelial-Mesenchymal Transition
,
Gene expression
,
Gene Expression Regulation, Neoplastic
,
Homeodomain Proteins - genetics
,
Homeodomain Proteins - metabolism
,
HOXA9
,
Humans
,
Lung - metabolism
,
Lung - pathology
,
Lung cancer
,
Lung Neoplasms - genetics
,
Lung Neoplasms - metabolism
,
Lung Neoplasms - pathology
,
MicroRNAs
,
MicroRNAs - genetics
,
miR-196b
,
Neoplasm Invasiveness - genetics
,
Neoplasm Invasiveness - pathology
,
NF-kappa B - metabolism
,
NF-κB
,
NSCLC
,
Up-Regulation
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