Details

Autor(en) / Beteiligte

• Mega, William M.
• Doyle-Eisele, Melanie
• Cass, Robert T.
• Kostrub, Corwin F.
• Sherwood, Robert L.
• Metz, Matthew A.
• Cirz, Ryan T.

Titel

Plazomicin is effective in a non-human primate pneumonic plague model

Ist Teil von

• Bioorganic & medicinal chemistry, 2016-12, Vol.24 (24), p.6429-6439

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2016

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• [Display omitted] The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15–331) LD50s] received placebo (n=12) or ‘humanized’ dose regimens (6.25, 12.5 or 25mg/kg every 24h) of plazomicin (n=52) after the onset of fever for a duration of 5 or 10days. All animals treated with placebo died, while 36 plazomicin-treated animals survived through study end. The majority (33/36) were either in the 10-day (high-/mid-/low-dose) or 5-day high-dose groups. The findings suggest an exposure range of plazomicin for treatment of pneumonic/bacteremic Y. pestis infection in humans.