Details

Autor(en) / Beteiligte

• Christensen, Jacob J., MSc
• Retterstøl, Kjetil, MD, PhD
• Godang, Kristin, BSc
• Roland, Marie Cecilie Paasche, MD, PhD
• Qvigstad, Elisabeth, MD, PhD
• Bollerslev, Jens, MD, PhD
• Ueland, Thor, PhD
• Henriksen, Tore, MD, PhD
• Holven, Kirsten B., PhD

Titel

LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors

Ist Teil von

• Journal of clinical lipidology, 2016-11, Vol.10 (6), p.1369-1378.e7

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Vast amounts of data show associations between maternal obesity, dysglycemia, diabetes, and undernutrition during pregnancy and increased cardiovascular disease risk in offspring. However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has scarcely been studied. Objective Our objective was to investigate the associations between elevated maternal LDL-C in pregnancy and CVD risk factors in 6-to-13-year-old offspring. Methods We recruited 6-to-13-year-old children whose mothers attended a pregnancy cohort and who had high or low cholesterol in pregnancy, defined as LDL-C over the 90th percentile or below the 10th percentile within the pregnancy cohort, respectively. We measured CVD risk factors in the children in the 2 groups. Results Maternal plasma LDL-C at gestational week 14 to 16 was 4.0 and 1.4 mmol/L in the hypercholesterolemic (n = 27) and hypocholesterolemic (n = 34) groups, respectively ( P  < .001). Interestingly, offspring plasma LDL-C was 0.4 mmol/L higher in children whose mothers had hypercholesterolemia during pregnancy ( P  < .01). We found no difference in birthweight or any other clinical or biochemical CVD risk factors or dietary intake between the children at 6–13 years. Conclusions Women with elevated LDL-C during early pregnancy have offspring with higher LDL-C already at the age of 6–13 years. Unless cholesterol-reducing measures are successfully implemented, the affected children may be at increased cardiovascular risk.