Chemical and Pharmaceutical Bulletin, 2017/02/01, Vol.65(2), pp.204-207
2017
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- Autor(en) / Beteiligte
- Titel
- Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 2017/02/01, Vol.65(2), pp.204-207
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B–D (2–4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC50 values ranging from 0.51 to 0.66 µM.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.c16-00743Titel-ID: cdi_proquest_miscellaneous_1846025350
- Format
- –
- Schlagworte
- Adenocarcinoma, Cell Line, Tumor, Circular dichroism, Cytotoxicity, Drug Screening Assays, Antitumor, Fractionation, homoisoflavane, homoisoflavanone, homoisopogon, Humans, Isoflavones - chemistry, Isoflavones - isolation & purification, Isoflavones - pharmacology, Lung cancer, Lungs, Melanoma, Methanol, Molecular Structure, NMR, Nuclear magnetic resonance, Ophiopogon - chemistry, Ophiopogon japonicus, Plant Extracts - chemistry, Plant Extracts - pharmacology, Plant Tubers - chemistry, Squamous cell carcinoma, Tubers