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Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions
Ist Teil von
Chemistry : a European journal, 2016-10, Vol.22 (41), p.14513-14517
Ort / Verlag
Germany: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A mechanochemical version of the Strecker reaction for the synthesis of α‐aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α‐aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker‐type multicomponent reaction allowed the one‐pot synthesis of tetrahydroisoquinolines after a subsequent internal N‐alkylation reaction.
The rolling stones: An efficient mechanochemical version of the Strecker reaction mediated by SiO2 was developed. The use of stone‐based milling media enabled the one‐pot multicomponent synthesis of α‐aminonitriles and tetrahydroisoquinolines in good to high yields (see figure).