Brain, behavior, and immunity, 2017-03, Vol.61, p.184-196
2017
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- The hippocampal transcriptomic signature of stress resilience in mice with microglial fractalkine receptor (CX3CR1) deficiency
- Ist Teil von
- Brain, behavior, and immunity, 2017-03, Vol.61, p.184-196
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • CX3CR1 deficiency confers resilience to the hedonic and cognitive effects of stress. • CX3CR1-/- mice exhibit resistance to stress-induced neurogenesis suppression. • CX3CR1-/- mice exhibit altered hippocampal microglial morphology. • Reduced IFN-regulated transcription in CX3CR1-/- mice associates with passive resilience. • Increased estrogenic-regulated transcription in CX3CR1-/- mice associates with active resilience.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2016.11.023Titel-ID: cdi_proquest_miscellaneous_1844353525
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Chronic unpredictable stress, CX3C Chemokine Receptor 1 - genetics, CX3C Chemokine Receptor 1 - metabolism, CX3CR1, Depression, Hippocampus, Hippocampus - metabolism, Igf2, Interferon, Male, Memory - physiology, MHC-I, Mice, Mice, Knockout, Microglia, Microglia - metabolism, Neurogenesis, Neurogenesis - physiology, Neurons - metabolism, Psychiatry, Resilience, Psychological, RNA sequencing, Signal Transduction, Stress, Stress, Psychological - genetics, Stress, Psychological - metabolism, Transcriptome