Details

Autor(en) / Beteiligte

• Rice, David
• Chansky, Kari
• Nowak, Anna
• Pass, Harvey
• Kindler, Hedy
• Shemanski, Lynn
• Opitz, Isabelle
• Call, Sergi
• Hasegawa, Seiki
• Kernstine, Kemp
• Atinkaya, Cansel
• Rea, Federico
• Nafteux, Philippe
• Rusch, Valerie W.
• Goldstraw, Peter
• Rami-Porta, Ramón
• Asamura, Hisao
• Beer, David
• Beyruti, Ricardo
• Crowley, John
• Detterbeck, Frank
• Eberhardt, Wilfried Ernst Erich
• Edwards, John
• Galateau-Sallé, Françoise
• Giroux, Dorothy
• Gleeson, Fergus
• Groome, Patti
• Huang, James
• Kennedy, Catherine
• Kim, Jhingook
• Kim, Young Tae
• Kingsbury, Laura
• Kondo, Haruhiko
• Krasnik, Mark
• Kubota, Kaoru
• Lerut, Antoon
• Lyons, Gustavo
• Marino, Mirella
• van Meerbeeck, Jan
• Mitchell, Alan
• Nakano, Takashi
• Nicholson, Andrew G.
• Peake, Michael
• Rice, Thomas
• Rosenzweig, Kenneth
• Ruffini, Enrico
• Rusch, Valerie
• Saijo, Nagahiro
• Van Schil, Paul
• Sculier, Jean-Paul
• Stratton, Kelly
• Suzuki, Kenji
• Tachimori, Yuji
• Thomas, Charles F.
• Travis, William
• Tsao, Ming S.
• Turrisi, Andrew
• Watanabe, Hirokazu
• Wu, Yi-Long
• Baas, Paul
• Erasmus, Jeremy
• Inai, Kouki
• Nackaerts, Kristiaan
• Falkson, Conrad
• Filosso, Pier Luigi
• Kondo, Kazuya
• Lucchi, Marco
• Okumura, Meinoshin
• Blackstone, Eugene
• Batirel, Hasan
• Bille, Andrea
• Pastorino, Ugo
• Cangir, Ayten K.
• Cedres, Susana
• Friedberg, Joseph S.
• Galateau-Salle, Francoise
• Hasagawa, Seiki
• Kernstine, Kemp H.
• Atinkaya Ozturk, Cansel
• de Perrot, Marc
• Rice, David C.
• Rintoul, Robert
• Spaggiari, Lorenzo
• Galetta, Domenico
• Syrigos, K.N.
• Thomas, Charles
• Weder, Walter
• Yoshimura, Masahiro

Titel

The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma

Ist Teil von

• Journal of thoracic oncology, 2016-12, Vol.11 (12), p.2100-2111

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Nodal categories for malignant pleural mesothelioma are derived from the lung cancer staging system and have not been adequately validated. The International Association for the Study of Lung Cancer developed a multinational database to generate evidence-based recommendations to inform the eighth edition of the TNM classification of malignant pleural mesothelioma. Data from 29 centers were entered prospectively (n = 1566) or by transfer of retrospective data (n = 1953). Survival according to the seventh edition N categories was evaluated using Kaplan-Meier survival curves and Cox proportional hazards regression analysis. Survival was measured from the date of diagnosis. There were 2432 analyzable cases: 1603 had clinical (c) staging, 1614 had pathologic (p) staging, and 785 had both. For clinically staged tumors there was no separation in Kaplan-Meier curves between cN0, cN1 or cN2 (cN1 versus cN0 hazard ratio [HR] = 1.06, p = 0.77 and cN2 versus cN1 HR = 1.04, p = 0.85). For pathologically staged tumors, patients with pN1 or pN2 tumors had worse survival than those with pN0 tumors (HR = 1.51, p < 0.0001) but no survival difference was noted between those with pN1 and pN2 tumors (HR = 0.99, p = 0.99). Patients with both pN1 and pN2 nodal involvement had poorer survival than those with pN2 tumors only (HR = 1.60, p = 0.007) or pN0 tumors (HR = 1.62, p < 0.0001). A recommendation to collapse both clinical and pN1 and pN2 categories into a single N category comprising ipsilateral, intrathoracic nodal metastases (N1) will be made for the eighth edition staging system. Nodes previously categorized as N3 will be reclassified as N2.