Clinical breast cancer, 2016-12, Vol.16 (6), p.520-526.e2
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Impact of Expression of Vimentin and Axl in Breast Cancer
- Ist Teil von
- Clinical breast cancer, 2016-12, Vol.16 (6), p.520-526.e2
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Micro-Abstract The receptor tyrosine kinase Axl has been reported to be a downstream effector of epithelial-to-mesenchymal transition and to be regulated by vimentin expression in preclinical models. Coexistence of vimentin-positive and Axl-high expression was significantly associated with triple-negative breast cancer and poor prognosis. Vimentin and Axl expression might contribute to the aggressive phenotype in breast cancer patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1526-8209eISSN: 1938-0666DOI: 10.1016/j.clbc.2016.06.015Titel-ID: cdi_proquest_miscellaneous_1842536354
- Format
- –
- Schlagworte
- Axl, Axl Receptor Tyrosine Kinase, Biomarkers, Tumor - metabolism, Breast Neoplasms - metabolism, Breast Neoplasms - mortality, Breast Neoplasms - pathology, Carcinoma, Ductal, Breast - metabolism, Carcinoma, Ductal, Breast - mortality, Carcinoma, Ductal, Breast - pathology, Carcinoma, Ductal, Breast - surgery, Disease-Free Survival, Female, Hematology, Oncology and Palliative Medicine, Humans, Immunohistochemistry, Japan - epidemiology, MCF-7 Cells, Middle Aged, Neoplasm Staging, Obstetrics and Gynecology, Prognosis, Prognostic factor, Proportional Hazards Models, Proto-Oncogene Proteins - metabolism, Receptor Protein-Tyrosine Kinases - metabolism, Survival, Triple Negative Breast Neoplasms - metabolism, Triple Negative Breast Neoplasms - mortality, Triple Negative Breast Neoplasms - pathology, Triple-negative breast cancer, Vimentin, Vimentin - metabolism