Details

Autor(en) / Beteiligte

• Schrader, Thomas O.
• Kasem, Michelle
• Ren, Albert
• Feichtinger, Konrad
• Al Doori, Bilal
• Wei, Jing
• Wu, Chunrui
• Dang, Huong
• Le, Minh
• Gatlin, Joel
• Chase, Kelli
• Dong, Jenny
• Whelan, Kevin T.
• Sage, Carleton
• Grottick, Andrew J.
• Semple, Graeme

Titel

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (24), p.5877-5882

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT2C receptor agonists are reported. An early lead containing a highly unique 6,6,7-ring system was optimized for both in vitro potency and selectivity at the related 5-HT2B receptor. Orally bioactive, potent, and selective 6,6,6-tricyclic 5-HT2C agonists were identified.