Details

Autor(en) / Beteiligte

• Erlinger, Serge

Titel

Obeticholic acid in primary biliary cholangitis

Ist Teil von

• Clinics and research in hepatology and gastroenterology, 2017-02, Vol.41 (1), p.3-5

Ort / Verlag

France

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Summary In a double-blind, randomized, placebo-controlled study including 217 patients with primary biliary cholangitis, the authors show that obeticholic acid (a potent farnesoid X agonist) administered with ursodeoxycholic acid or as monotherapy significantly decreases serum alkaline phosphatase and bilirubin when compared to placebo. Pruritus (and serious adverse effects) was observed more frequently in obeticholic acid-treated patients than in controls, in spite of a decrease in serum bile acid concentration. These results are encouraging, but more studies are needed on clinical efficacy and safety before obeticholic acid can be widely recommended.