Details

Autor(en) / Beteiligte

• Palisi, Angelica
• Grimaldi, Manuela
• Sabatini, Paola
• Montoro, Paola
• Scrima, Mario
• Rodriquez, Manuela
• D’Ursi, Anna Maria

Titel

A serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome

Ist Teil von

• Journal of pharmaceutical and biomedical analysis, 2017-01, Vol.133, p.90-95

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2017

Quelle

ScienceDirect

Beschreibungen/Notizen

• •Characteristic metabolomic profile of patients suffering of antiphospholipid syndrome.•Stratification of antiphospholipid syndrome (APS) according to the gender.•APS metabolic fingerprints as potential serum biomarkers. Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show that individuals suffering APS have a characteristic metabolomic profile with abnormalities associated to the metabolism of methyl group donors, ketone bodies and amino acids. We have identified for the first time the metabolomic fingerprint characterizing APS disease having potential application to improve APS timely diagnosis and appropriate therapeutic approaches.