Biochemical pharmacology, 2014-07, Vol.90 (1), p.25-33
2014
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer
- Ist Teil von
- Biochemical pharmacology, 2014-07, Vol.90 (1), p.25-33
- Ort / Verlag
- England: Elsevier Inc
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Hydroxytyrosol is able to protect the ADR-associated mitochondria damage by decreasing oxidative stress and maintaining the integrity of METC. HT, hydroxytyrosol; ADR, adriamycin; METC, mitochondrial electron transport chain; ROS, reactive oxygen species. Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial dysfunction. Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer. Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol. Cardiac disturbances at the cellular and mitochondrial level, mitochondrial electron transport chain complexes I–IV and apoptosis-inducing factor, and oxidative stress markers have been analyzed. Hydroxytyrosol improved the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered mitochondria and oxidative damage. These results suggest that hydroxytyrosol improve the mitochondrial electron transport chain. This study demonstrates that hydroxytyrosol protect rat heart damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/j.bcp.2014.04.001Titel-ID: cdi_proquest_miscellaneous_1837327375
- Format
- –
- Schlagworte
- Animals, Antioxidants - pharmacology, Apoptosis Inducing Factor - metabolism, Apoptosis-inducing factor, Chemo toxicity, Doxorubicin, Electron transport chain, Electron Transport Complex I - metabolism, Electron Transport Complex II - metabolism, Electron Transport Complex III - metabolism, Electron Transport Complex IV - metabolism, Fatty Acids - chemistry, Fatty Acids - metabolism, Female, Gas Chromatography-Mass Spectrometry, Heart Diseases - chemically induced, Heart Diseases - complications, Heart Diseases - metabolism, Hydroxytyrosol, Immunoblotting, Mammary Neoplasms, Animal - complications, Mammary Neoplasms, Animal - metabolism, Microscopy, Electron, Mitochondria, Heart - drug effects, Mitochondria, Heart - metabolism, Mitochondria, Heart - ultrastructure, Oxidation-Reduction - drug effects, Oxidative stress, Oxidative Stress - drug effects, Phenylethyl Alcohol - analogs & derivatives, Phenylethyl Alcohol - pharmacology, Protein damage, Rats, Rats, Sprague-Dawley