Details

Autor(en) / Beteiligte

• Boshra, Sylvia A
• Hussein, Mohammed A

Titel

THE PROTECTIVE ROLE OF COLCHICINE ON DICLOFENAC SODIUM INDUCED HEPATORENAL TOXICITY IN ALBINO RATS MODEL

Ist Teil von

• International journal of pharmaceutical sciences and research, 2014-12, Vol.5 (12), p.5136-5136

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Diclofenac (DIC) is widely used as an anti-inflammatory drug and it is used, as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/kg body weight daily for 28 days. Oral administration of colchicine at a concentration of 10 mu g/kg b.w daily for 28 days, showed a significant decrease in plasma AST, ALT and creatinine, as well as hepatic and renal thiobarbituric acid reactive substances and hydroperoxides. The treatment also resulted in a significant increase in GSH, SOD, CAT and GPx in the liver and kidney of DIC treated rats. The results clearly suggest, that the colchicine treated group may effectively normalize the impaired antioxidant status in DIC- induced liver and kidney injury than the vitamin C-treated groups. However, colchicine rapid protective effects against lipid peroxidation by scavenging of free radicals reduce the risk of oxidative complications.