Details

Autor(en) / Beteiligte

• Sawicki, E
• Schellens, J.H.M
• Beijnen, J.H
• Nuijen, B

Titel

Inventory of oral anticancer agents: pharmaceutical formulation aspects with focus on the solid dispersion technique

Ist Teil von

• Cancer treatment reviews, 2016-11, Vol.50, p.247-263

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • This review discusses drug dissolution from a pharmaceutical formulation and focuses on the solid dispersion technique. • There are currently 72 oncolytics licensed as an oral formulation in Europe, the majority of them are crystalline physical mixture formulations. 3 oral oncolytics are licensed as a solid dispersion: vemurafenib, regorafenib and everolimus. • In 47% of currently licensed oral oncolytics, poor dissolution contributes to low and unpredictable absorption. For these oncolytics there seems to be room for improving the formulation and a solid dispersion could be considered.