Details

Autor(en) / Beteiligte

• Cimenti, Christina
• Schlagenhauf, Axel
• Leschnik, Bettina
• Fröhlich-Reiterer, Elke
• Jasser-Nitsche, Hildegard
• Haidl, Harald
• Suppan, Elisabeth
• Weinhandl, Gudrun
• Leberl, Maximilian
• Borkenstein, Martin
• Muntean, Wolfgang E

Titel

Only minor changes in thrombin generation of children and adolescents with type 1 diabetes mellitus – A case-control study

Ist Teil von

• Thrombosis research, 2016-12, Vol.148, p.45-49

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background: Micro- and macrocvascular diseases are frequent complications in patients with diabetes. Hypercoagulability may contribute to microvascular alterations. Objective: In this study, we investigated whether type 1 diabetes in children is associated with a hypercoagulable state by performing a global function test of coagulation – the thrombin generation assay. Subjects: 75 patients with type 1 diabetes aged between 2 and 19 years were compared to an age-matched healthy control group. Diabetes patients were divided into high-dose and low-dose insulin cohorts with a cut-off at 0.8 U kg-1 d-1. Methods: Measurements were performed with platelet poor plasma using Calibrated Automated Thrombography and 1 pM or 5 pM tissue factor. Additionally, we quantified prothrombin fragments F 1 + 2, thrombin-antithrombin complex, prothrombin, tissue factor pathway inhibitor, and antithrombin. Results: Patients with type 1 diabetes exhibited a significantly shorter of lag time as well as decreased thrombin peak and endogenous thrombin potential compared to control subjects with 5 pM but not with 1 pM tissue factor. In high-dose insulin patients peak thrombin generation was higher and time to peak shorter than in low-dose patients. Thrombin-antithrombin complex was decreased in patients with type 1 diabetes, whereas prothrombin fragments F 1 + 2 was comparable in both groups. Thrombin generation parameters did not correlate with parameters of metabolic control and the duration of diabetes. Conclusions: Taken together, we found only minor changes of thrombin generation in children and adolescents with type 1 diabetes which - in contrast to type 2 diabetes – do not argue for a hypercoagulable state.