Details

Autor(en) / Beteiligte

• Fu, Boshi
• Huang, Jinguo
• Chen, Yuqi
• Wang, Yafen
• Xue, Tianrui
• Xu, GuoHua
• Wang, Shaoru
• Zhou, Xiang

Titel

Right-handed and left-handed G-quadruplexes have the same DNA sequence: distinct conformations induced by an organic small molecule and potassium

Ist Teil von

• Chemical communications (Cambridge, England), 2016-01, Vol.52 (65), p.10052-10055

Ort / Verlag

England

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Herein, we report two distinct G-quadruplex conformations of the same G-rich oligonucleotide, regulated by a small molecule. This is the first report in which both right- and left-handed G-quadruplex conformations have been obtained from the same sequence. We discriminated these two distinct conformations and investigated their kinetics and thermodynamics.