Details

Autor(en) / Beteiligte

• Wang, Zheng
• Wang, Ying‐shuai
• Chang, Zhi‐min
• Li, Li
• Zhang, Yi
• Lu, Meng‐meng
• Zheng, Xiao
• Li, Mingqiang
• Shao, Dan
• Li, Jing
• Chen, Li
• Dong, Wen‐fei

Titel

Berberine‐loaded Janus nanocarriers for magnetic field‐enhanced therapy against hepatocellular carcinoma

Ist Teil von

• Chemical biology & drug design, 2017-03, Vol.89 (3), p.464-469

Ort / Verlag

England

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Berberine, an bioactive isoquinolin alkaloid from traditional Chinese herbs, is considered to be a promising agent based on its remarkable activity against hepatocellular carcinoma. However, the clinical application of this nature compound had been hampered owing to its properties such as poor aqueous solubility, low gastrointestinal absorption, and reduced bioavailability. Therefore, we developed Janus magnetic mesoporous silica nanoparticles (Fe3O4‐mSiO2 NPs) consisting of a Fe3O4 head for magnetic targeting and a mesoporous SiO2 body for berberine delivery. A pH‐sensitive group was introduced on the surface of mesoporous silica for berberine loading to develop a tumor microenvironment‐responsive nanocarrier, which exhibited uniform morphology, good superparamagnetic properties, high drug‐loading amounts, superior endocytic ability, and low cytotoxicity. Berberine‐loaded Fe3O4‐mSiO2 NPs exerted extraordinarily high specificity for hepatocellular carcinoma cells, which was due to the pH‐responsive berberine release, as well as higher endocytosis capacity in hepatocellular carcinoma cells rather than normal liver cells. More importantly, an external magnetic field could significantly improve antitumor activity of Ber‐loaded Fe3O4‐mSiO2 NPs through enhancing berberine internalization. Taken together, our results suggest that Janus nanocarriers driven by the magnetic field may provide an effective and safe way to facilitate clinical use of berberine against hepatocellular carcinoma. We have developed Janus magnetic mesoporous silica nanoparticles (Fe3O4‐mSiO2 NPs) with exhibited uniform morphology, good superparamagnetic properties, high drug‐loading amounts, superior endocytic ability, pH‐responsive drug release and low cytotoxicity for berberine (Ber) delivery. An external magnetic field could significantly improve antitumor activity of Ber‐loaded Fe3O4‐mSiO2 NPs through enhancing berberine internalization. Janus nanocarriers driven by the magnetic field may provide an effective and safe way to facilitate clinical use of berberine against hepatocellular carcinoma.