Details

Autor(en) / Beteiligte

• Jia, Ming-Yan
• Wang, Yu
• Liu, Yang
• Niu, Li-Ya
• Feng, Liang

Titel

BODIPY-based self-assembled nanoparticles as fluorescence turn-on sensor for the selective detection of zinc in human hair

Ist Teil von

• Biosensors & bioelectronics, 2016-11, Vol.85, p.515-521

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Zinc plays important roles in regulating physiological and pathological processes. Regrettably, mild to moderate zinc deficiency is common worldwide. Hair Zn2+ concentration, which reflects a zinc storage status, is useful for tracking trends in zinc status within populations. In this work, we report BODIPY-based self-assembled nanoparticles (NPs) as fluorescence turn-on sensor for the selective sensing of Zn2+ in human hair. The BODIPY monomers (BAN) self-assemble in aqueous medium to form nonfluorescent NPs. In the presence of Zn2+ ions, the NPs selectively show an obvious turn-on fluorescence change. This selective response of the NPs allows the determination and quantification of Zn2+ in human hair with a detection limit of 61.3nM. This study demonstrates that the small molecule self-assembled nanoparticle is a versatile and useful tool, and shows great potential for applications in sensing of important analytes in biological systems. [Display omitted] •The BODIPY monomers self-assemble to form nonfluorescent NPs.•BODIPY-based self-assembled nanoparticles were used as fluorescence turn-on sensor.•Zn2+ in human hair was quantitatively detected.•The detection limit for Zn2+ determination was calculated as low as 61.3nM.