Details

Autor(en) / Beteiligte

• Song, Yuan-qing
• Gao, Yun-long
• Pan, Zhi-cheng
• Zhang, Yi
• Li, Jie-hua
• Wang, Kun-jie
• Li, Jian-shu
• Tan, Hong
• Fu, Qiang

Titel

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

Ist Teil von

• Chinese journal of polymer science, 2016-06, Vol.34 (6), p.679-687

Ort / Verlag

Beijing: Chinese Chemical Society and Institute of Chemistry, CAS

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane （WPU）haepafin release coating system （WPU/heparin） is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy （ATR-FTIR） and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time （APTT）, thrombin time （TT）, hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.