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Current discussions of the allowed two-Higgs-doublet model parameter space after LHC run 1 and the prospects for run 2 are commonly phrased in the context of a quasidegenerate spectrum for the new scalars. Here, we discuss the generic situation of a two-Higgs-doublet model with a nondegenerate spectrum for the new scalars. This is highly motivated from a cosmological perspective since it naturally leads to a strongly first-order electroweak phase transition that could explain the matter-antimatter asymmetry in the Universe. While constraints from measurements of Higgs signal strengths do not change, those from searches of new scalar states get modified dramatically once a nondegenerate spectrum is considered.