Details

Autor(en) / Beteiligte

• Kiuchi, Shizuka, MD
• Tomaru, Utano, MD, PhD
• Ishizu, Akihiro, MD, PhD
• Imagawa, Makoto
• Kiuchi, Takayuki, MD
• Iwasaki, Sari, MD, PhD
• Suzuki, Akira, MD, PhD
• Otsuka, Noriyuki, MD, PhD
• Deguchi, Takahiro
• Shimizu, Tomohiro
• Marukawa, Katsuji
• Matsuno, Yoshihiro, MD, PhD
• Kasahara, Masanori, MD, PhD

Titel

Expression of cathepsins V and S in thymic epithelial tumors

Ist Teil von

• Human pathology, 2017-02, Vol.60, p.66-74

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Cathepsins are a group of proteolytic enzymes of the endosomal/lysosomal pathway involved in the thymic development of T cells restricted by major histocompatibility complex class II molecules. In the normal thymus, cathepsin V (CTV) and cathepsin S (CTS) are expressed in cortical and medullary epithelial cells, respectively. To investigate whether cathepsins could serve as a diagnostic marker, we performed immunohistochemical analysis for CTV and CTS in 77 cases of thymic epithelial tumors. Almost all cases (59/60) of thymoma expressed CTV, whereas 28 out of 60 cases of thymoma expressed CTS. Notably, CTS was expressed in most cases of type A and type AB thymomas, but not in type B thymoma. The expression of cathepsins in type AB thymoma showed clear correlation with histological features; CTV was found predominantly in the type B component, and CTS was frequently expressed in the type A component. In thymic carcinoma, CTV was expressed in less than half cases (7/17), and the ratio of CTS-positive cases was equivalent to that of thymoma (8/17). Cases of CTV-negative thymic carcinoma tended to have a higher incidence of recurrence than CTV-positive cases. Although further studies with a larger number of cases are required to confirm the utility of cathepsin immunostaining, CTV and CTS appear to serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors.