Details

Autor(en) / Beteiligte

• Brunner, Patrick M.
• Silverberg, Jonathan I.
• Guttman-Yassky, Emma
• Paller, Amy S.
• Kabashima, Kenji
• Amagai, Masayuki
• Luger, Thomas A.
• Deleuran, Mette
• Werfel, Thomas
• Eyerich, Kilian
• Stingl, Georg
• Bagot, Martine
• Hijnen, Dirk Jan
• Ardern-Jones, Michael
• Reynolds, Nick
• Spuls, Phyllis
• Taieb, Alain

Titel

Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder

Ist Teil von

• Journal of investigative dermatology, 2017-01, Vol.137 (1), p.18-25

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities.