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Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: valid outcome prediction of clozapine therapy in a three-year follow-up
Ist Teil von
The international journal of neuropsychopharmacology, 1999-06, Vol.2 (2), p.83-93, Article S1461145799001418
Ort / Verlag
England: Cambridge University Press
Erscheinungsjahr
1999
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Reliability, specificity, and validity of three event-related potential (ERP) indices of non-attended and attended
auditory information processing [the mismatch negativity (MMN), the novelty-P3a and the target-P3b] were
assessed in 21 healthy subjects and 25 schizophrenic patients while performing a visual discrimination task
(Ignore condition) and, subsequently, an auditory discrimination task (Attend condition). Re-test reliability, as
measured in a subset of 10 healthy subjects and 9 patients respectively, ranged from r=0.4 to r=0.8. In both
groups P3a was found to be smaller in the Ignore than in the Attend condition. Patients had significantly larger
P3a amplitudes than healthy subjects while their MMN and P3b amplitudes were smaller. Two ERP factors
were extracted in healthy subjects: (1) ‘novelty reaction’ with high loading scores for P3a and (2) ‘deviant
detection’ with high loading scores for MMN. P3b was predominantly loading on the first factor thus
confirming partly overlapping P3a and P3b generators. However, considerable variance was also shared by the
second factor, particularly in patients. External validity of the ERP factors was confirmed post hoc. Particularly
ERP indices of deviant detection were found to be associated with negative symptoms. In order to assess
further clinical relevance, therapy response to clozapine was followed-up over 3 yr in a sub-sample of 17
patients. Poor treatment response was associated with high Novelty Factor scores and large P3a amplitudes
whereas good response was associated with high Deviant Factor scores and relatively intact MMN. It is
concluded that ERP abnormalities provide a severity index of brain impairment and a measure of predicting
therapeutic outcome.
Sprache
Englisch
Identifikatoren
ISSN: 1461-1457
eISSN: 1469-5111
DOI: 10.1017/S1461145799001418
Titel-ID: cdi_proquest_miscellaneous_1835498340
Format
–
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