Details

Autor(en) / Beteiligte

• Hawker, G.A
• Croxford, R
• Bierman, A.S
• Harvey, P
• Ravi, B
• Kendzerska, T
• Stanaitis, I
• King, L.K
• Lipscombe, L

Titel

Osteoarthritis-related difficulty walking and risk for diabetes complications

Ist Teil von

• Osteoarthritis and cartilage, 2017-01, Vol.25 (1), p.67-75

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Objectives To examine the effect of Osteoarthritis (OA)-related difficulty walking on risk for diabetes complications in persons with diabetes and OA. Design A population cohort aged 55+ years with symptomatic hip and knee OA was recruited 1996–98 and followed through provincial administrative data to 2015 ( n  = 2,225). In those with confirmed OA (examination and radiographs) and self-reported diabetes at baseline ( n  = 359), multivariate Cox regression modeling was used to examine the relationship between baseline difficulty walking (Health Assessment Questionnaire (HAQ) difficulty walking score; use of walking aid) and time to first diabetes-specific complication (hospitalization for hypo- or hyperglycemia, infection, amputation, retinopathy, or initiation of chronic renal dialysis) and cardiovascular (CV) events. Results Participants’ mean baseline age was 71.4 years; 66.9% were female, 77.7% had hypertension, 54.0% had pre-existing CV disease, 42.9% were obese and 15.3% were smokers. Median HAQ difficulty walking score was 2/3 indicating moderate to severe walking disability; 54.9% used a walking aid. Over a median 6.1 years, 184 (51.3%) experienced one or more diabetes-specific complications; 191 (53.2%) experienced a CV event over a median 5.7 years. Greater baseline difficulty walking was associated with shorter time to the first diabetes-specific complication (adjusted HR per unit increase in HAQ walking 1.24, 95% CI 1.04–1.47, P  = 0.02) and CV event (adjusted HR for those using a walking aid 1.35, 95% CI 1.00–1.83, P  = 0.04). Conclusions In a population cohort with OA and diabetes, OA-related difficulty walking was a significant – and potentially modifiable – risk factor for diabetes complications.