Details

Autor(en) / Beteiligte

• Uguen, Arnaud, MD, PhD

Titel

About RAS mutation–specific immunohistochemistry in formalin-fixed paraffin-embedded tumor samples

Ist Teil von

• Human pathology, 2017-02, Vol.60, p.208-209

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

ScienceDirect

Beschreibungen/Notizen

• Other studies also reported good performances of this immunohistochemistry in melanoma samples with, nevertheless, some discordant results between molecular analyses and immunohistochemistry, with reported sensitivity of 92.3% to 100% and specificity of 98.9% to 100% [3-7]. Besides these good performances, SP174 immunohistochemistry permitted testing of intra- and intertumoral homogeneity of mutations in patients suffering from NRAS-mutated metastatic melanomas [8]. In colorectal carcinoma, RAS mutations cause primary resistance to cetuximab anti-EGFR therapy, and searching for KRAS and NRAS mutations in colorectal samples has in this manner become mandatory to treat patients with metastatic disease.