Details

Autor(en) / Beteiligte

• Pérez-Gómez, Marta
• García-López, José-Antonio

Titel

Trapping σ-Alkyl-Palladium(II) Intermediates with Arynes Encompassing Intramolecular C−H Activation: Spirobiaryls through Pd-Catalyzed Cascade Reactions

Ist Teil von

• Angewandte Chemie International Edition, 2016-11, Vol.55 (46), p.14389-14393

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A palladium‐catalyzed cascade reaction based on the trapping of transient alkyl–PdII intermediates with arynes encompassing a C−H activation step has been developed. This synthetic pathway gives rise to hetero‐spirocyclic scaffolds containing a biaryl motif, and opens up new synthetic strategies in the design of cascade reactions since it gathers several aspects of Pd chemistry, i.e., intra‐ and intermolecular carbopalladation of unsaturated species, C−H activation and C−C coupling processes. From simple to complex: A palladium‐catalyzed cascade Heck carbopalladation/C−H activation/aryne insertion provides easy access to spirobiaryls. The process takes advantage of several aspects of Pd chemistry, i.e., intra‐ and intermolecular carbopalladation of unsaturated species, C−H activation, and C−C coupling processes.