Details

Autor(en) / Beteiligte

• Riis, Robert Gabriel Coumine
• Gudbergsen, Henrik
• Simonsen, Ole
• Henriksen, Marius
• Al-Mashkur, Nasir
• Eld, Mikkel
• Petersen, Kristian Kjær
• Kubassova, Olga
• Bay Jensen, Anne C
• Damm, Janus
• Bliddal, Henning
• Arendt-Nielsen, Lars
• Boesen, Mikael Ploug, MD, PhD

Titel

The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis: a cross-sectional study

Ist Teil von

• Osteoarthritis and cartilage, 2017-02, Vol.25 (2), p.272-280

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Objectives To investigate the association between MRI, macroscopic and histological assessments of synovitis in end-stage knee osteoarthritis (KOA). Methods Synovitis of end-stage osteoarthritic knees was assessed using non-contrast-enhanced (CE), CE-MRI and dynamic-CE (DCE)-MRI prior to total knee replacement and correlated with microscopic and macroscopic assessments of synovitis obtained intraoperatively. Multiple bivariate correlations were used with a pre-specified threshold of 0.70 for significance. Also, multiple regression analyses with different subsets of MRI-variables as explanatory variables and the histology score as outcome variable were performed with the intention to find MRI-variables that best explain the variance in histological synovitis (i.e. highest R2 ). A stepped approach was taken starting with basic characteristics and non-CE MRI-variables (model 1), after which CE-MRI-variables were added (model 2) with the final model also including DCE-MRI-variables (model 3). Results 39 patients (56.4% women, mean age 68 years, Kellgren-Lawrence grade 4) had complete MRI and histological data. Only the DCE-MRI variable MExNvoxel (surrogate of the volume and degree of synovitis) and the macroscopic score showed correlations above the pre-specified threshold for acceptance with histological inflammation. The maximum R2 -value obtained in Model 1 was R2 =0.39. In Model 2, where the CE-MRI-variables were added, the highest R2 =0.52. In Model 3, a four-variable model consisting of the gender, one CE-MRI and two DCE-MR-variables yielded a R2 =0.71. Conclusion DCE-MRI is correlated with histological synovitis in end-stage KOA and the combination of CE and DCE-MRI may be a useful, non-invasive tool in characterising synovitis in KOA.