Details

Autor(en) / Beteiligte

• Wang, Dong-Chao
• Xie, Ming-Sheng
• Guo, Hai-Ming
• Qu, Gui-Rong
• Zhang, Meng-Cheng
• You, Shu-Li

Titel

Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles

Ist Teil von

• Angewandte Chemie (International ed.), 2016-11, Vol.55 (45), p.14111-14115

Auflage

International ed. in English

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A highly enantioselective dearomative [3+2] cycloaddition of benzothiazole has been successfully developed. A wide range of benzothiazoles and cyclopropane‐1,1‐dicarboxylates are suitable substrates for this reaction. The desired hydropyrrolo[2,1‐b]thiazole compounds were obtained in excellent enantioselectivity and yields (up to 97 % ee and 97 % yield). With the same catalytic system, a highly efficient kinetic resolution of 2‐substituted cyclopropane‐1,1‐dicarboxylates was also realized. A highly enantioselective dearomative [3+2] cycloaddition of benzothiazole has been successfully developed. A wide range of benzothiazoles and cyclopropane‐1,1‐dicarboxylates are suitable substrates for this reaction. The desired hydropyrrolo[2,1‐b]thiazole compounds were obtained in excellent enantioselectivity and yields. With the same catalytic system, a highly efficient kinetic resolution of 2‐substituted cyclopropane‐1,1‐dicarboxylates was also realized.