Details

Autor(en) / Beteiligte

• Shields, Carol L., M.D
• Alset, Adel E., M.D
• Boal, Nina S., B.A
• Casey, Mairghread G., B.S
• Knapp, Austen N., B. S
• Sugarman, Jordan A., B.S
• Schoen, Marisa A., B.A
• Gordon, Phillip S., B.A
• Douglass, Alexzandra M., B.S
• Sioufi, Kareem, M.D
• Say, Emil A.T., M.D
• Shields, Jerry A., M.D

Titel

Conjunctival Tumors in 5002 Cases. Comparative Analysis of Benign versus Malignant Counterparts. The 2016 James D. Allen Lecture

Ist Teil von

• American journal of ophthalmology, 2017-01, Vol.173, p.106-133

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Purpose To evaluate frequency of conjunctival tumors in all ages and compare benign versus (vs) malignant counterparts. Design Retrospective series. Methods Setting: Tertiary referral center Study population 5002 patients Observation Clinical features Main Outcome Measure Differentiation benign from malignant counterparts Results The tumor was benign (52%), premalignant (18%), or malignant (30%). Malignant tumors included melanoma (12%), squamous cell carcinoma (9%), lymphoma (7%), and others. Comparison of PAM vs melanoma revealed melanoma with greater median patient age (54 vs 61 years, p<0.0001), male sex (35% vs 49%, p<0.0001), location in fornix (2% vs 6%, p=0.0016) and tarsus (1% vs 4%, p=0.0018), larger median basal diameter (6 vs 8 mm, p<0.0001) and thickness (<1 vs 1 mm, p<0.0001), and intralesional cysts (0% vs 7%, p<0.0001), feeder vessels (10% vs 48%, p<0.0001), intrinsic vessels (4% vs 33%, p<0.0001), and hemorrhage (<1% vs 3%, p=0.0001). Ccomparison of CIN vs SCC revealed SCC with greater diffuse involvement (1% vs 8%, p<0.0001), and larger median basal diameter (7 vs 8 mm, p<0.0001) and thickness (1 mm vs 2 mm, p<0.0001).Comparison of BRLH vs lymphoma revealed lymphoma with greater median patient age (50 vs 61 years, p<0.0001), fornix location (32% vs 54%, p<0.0001), larger median basal diameter (10 vs 20 mm, p<0.0001) and less involvement of nasal region (50% vs 23%, p<0.0001). Conclusion In an ocular oncology practice, conjunctival tumors are benign (52%), premalignant (18%), or malignant (30%). Malignant tumors tend to occur in older patients and demonstrate greater basal diameter and thickness, compared to benign counterparts.