Details

Autor(en) / Beteiligte

• Deepagan, V. G
• You, Dong Gil
• Um, Wooram
• Ko, Hyewon
• Kwon, Seunglee
• Choi, Ki Young
• Yi, Gi-Ra
• Lee, Jun Young
• Lee, Doo Sung
• Kim, Kwangmeyung
• Kwon, Ick Chan
• Park, Jae Hyung

Titel

Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

Ist Teil von

• Nano letters, 2016-10, Vol.16 (10), p.6257-6264

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nanocomposites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.