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To investigate bioactive compounds potentially involved in the biotic interactions exhibited by Phlomis purpurea (Lamiaceae) in rhizospheres infested with Phytophthora cinnamomi, the plant rhizome was chemically analysed. The nortriterpenoid (17S)-2α,3α,11α,23,24-pentahydroxy-19(18 → 17)-abeo-28-norolean-12-en-18-one, was isolated and its structure was elucidated by comprehensive spectroscopic analysis, chiefly using 2D NMR experiments, and X-ray analysis. It was shown to be exuded by roots and to exhibit anti-Phytophthora and antitumor activities.
The nortriterpenoid 1 isolated from Phlomis purpurea roots was structurally characterized, evaluated for its activity against Phytophthora species and tumor cell lines and shown to be exuded. [Display omitted]
•A previously undescribed nortriterpene from Phlomis purpurea roots was structurally characterized.•This compound is constitutively exuded by Phlomis purpurea roots.•It is bioactive against phytopathogen Phytophthora species and tumor cell lines.•It could be involved in biotic interactions shown by the plant in rhizospheres.