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Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression
Ist Teil von
Biochemical and biophysical research communications, 2016-10, Vol.479 (4), p.715-720
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
Activin belongs to transforming growth factor (TGF)-β super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew would be conserved across embryonic and adult stem cells. In this study, we tried to determine the effect of activin signaling pathway in regulation of cancer stem cells as a potential target for cancer therapy in clinical trials. A population of colorectal cancer cells was selected by the treatment of activin A. This population of cell possessed stem cell character with sphere formation ability. We demonstrated activin pathway enhanced the colorectal cancer stem cells self-renew and contribute to colorectal cancer progression in vivo. Targeting activin pathway potentially provide effective strategy for colorectal cancer therapy.
•Activin pathway contributes to maintain colorectal cancer stem cells.•Activin pathway inhibition suppresses colorectal cancer stem cell tumor formation.•SB431542 inhibit tumor formation in vivo by blocking activin receptor.